Elena Santagostino Selected Research

Factor IX (Coagulation Factor IX)

5/2020	Long-Term Safety and Efficacy of Nonacog Beta Pegol (N9-GP) Administered for at Least 5 Years in Previously Treated Children with Hemophilia B.
4/2020	Long-Term Safety and Efficacy of Recombinant Coagulation Factor IX Albumin Fusion Protein (rIX-FP) in Previously Treated Pediatric Patients with Hemophilia B: Results from a Phase 3b Extension Study.
1/2020	Long-term safety and efficacy of rIX-FP prophylaxis with extended dosing intervals up to 21 days in adults/adolescents with hemophilia B.
1/2020	Simplifying surgery in haemophilia B: Low factor IX consumption and infrequent infusions in surgical procedures with rIX-FP.
10/2019	Systematic review and analysis of efficacy of recombinant factor IX products for prophylactic treatment of hemophilia B in comparison with rIX-FP.
2/2019	Inhibitors in haemophilia A and B: Management of bleeds, inhibitor eradication and strategies for difficult-to-treat patients.
1/2018	GlycoPEGylated recombinant factor IX for hemophilia B in context.
9/2016	Long-acting recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in children. Results of a phase 3 trial.
5/2016	Nonacog beta pegol (N9-GP) in haemophilia B: A multinational phase III safety and efficacy extension trial (paradigm™4).
5/2016	Transforming the treatment for hemophilia B patients: update on the clinical development of recombinant fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP).

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Elena Santagostino Research Topics

Disease

79	Hemophilia A (Haemophilia) 01/2022 - 08/2004
41	Hemorrhage 04/2022 - 01/2002
16	Hemophilia B (Haemophilia B) 05/2020 - 01/2011
7	Infections 01/2020 - 08/2005
5	Joint Diseases (Joint Disease) 09/2018 - 04/2009
4	Chronic Hepatitis C 01/2020 - 02/2002
3	Liver Diseases (Liver Disease) 04/2022 - 09/2018
2	Metrorrhagia (Spotting) 05/2021 - 01/2017
2	HIV Infections (HIV Infection) 01/2020 - 01/2015
2	Fibrosis (Cirrhosis) 01/2020 - 10/2006
2	Disease Progression 06/2014 - 07/2010
1	Thrombocytopenia (Thrombopenia) 04/2022
1	Hepatitis C 11/2018
1	Osteoporosis 11/2018
1	Injection Site Reaction 01/2017
1	Inflammation (Inflammations) 01/2017
1	Thrombosis (Thrombus) 01/2017
1	Thrombotic Microangiopathies 01/2017
1	Vascular System Injuries 06/2015
1	Atrial Fibrillation 12/2009
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2009
1	Acute Coronary Syndrome 12/2009
1	Pain (Aches) 04/2009
1	Wounds and Injuries (Trauma) 01/2008
1	Vomiting 10/2006
1	Afibrinogenemia (Fibrinogen Deficiency) 05/2006

Drug/Important Bio-Agent (IBA)

49	Factor VIII (Coagulation Factor VIII)IBA 01/2022 - 08/2005
13	Blood Coagulation Factors (Coagulation Factor)IBA 01/2021 - 01/2002
13	Factor IX (Coagulation Factor IX)FDA LinkGeneric 05/2020 - 09/2012
10	emicizumabIBA 05/2021 - 01/2017
7	recombinant FVIIa (rFVIIa)FDA Link 09/2018 - 03/2003
6	Factor VIIa (Activated Factor VII)IBA 05/2021 - 09/2013
6	AlbuminsIBA 04/2020 - 09/2012
6	Recombinant Fusion ProteinsIBA 04/2020 - 09/2012
5	BAY 94-9027IBA 07/2021 - 11/2019
5	Proteins (Proteins, Gene)FDA Link 04/2020 - 09/2013
5	Neutralizing AntibodiesIBA 09/2018 - 03/2003
4	recombinant factor VIII N8IBA 05/2020 - 01/2014
4	Antiviral Agents (Antivirals)IBA 01/2020 - 04/2006
4	Prothrombin (Factor II)IBA 09/2018 - 10/2002
3	recombinant factor VIII SQIBA 05/2020 - 08/2004
3	nonacog beta pegolIBA 05/2020 - 05/2016
3	InterferonsIBA 01/2020 - 02/2002
3	Thrombin FDA Link 01/2019 - 10/2002
3	Factor V (Coagulation Factor V)IBA 11/2003 - 10/2002
2	Heme (Haem)IBA 01/2022 - 01/2019
2	CoagulantsIBA 01/2021 - 01/2019
2	factor VIII-Fc fusion proteinIBA 01/2021 - 05/2020
2	Pharmaceutical PreparationsIBA 11/2020 - 09/2018
2	Human Serum Albumin FDA LinkGeneric 01/2020 - 09/2012
2	von Willebrand FactorIBA 07/2019 - 05/2016
2	VaccinesIBA 07/2019 - 07/2010
2	Factor IXa (Coagulation Factor IXa)IBA 01/2019 - 01/2017
2	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/2018 - 04/2006
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 06/2014
2	Factor X (Stuart Factor)IBA 01/2017 - 10/2002
2	Hemostatics (Antihemorrhagics)IBA 01/2016 - 05/2006
2	AntibodiesIBA 10/2015 - 01/2013
2	Biological ProductsIBA 01/2014 - 10/2013
2	Ribavirin (Virazole)FDA LinkGeneric 10/2006 - 02/2002
2	Alanine Transaminase (SGPT)IBA 10/2006 - 07/2003
1	avatrombopagIBA 04/2022
1	Thrombopoietin ReceptorsIBA 04/2022
1	factor IX Fc fusion proteinIBA 01/2022
1	human F8 protein FDA Link 06/2020
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 01/2020
1	Carboxypeptidase B2 (Thrombin Activatable Fibrinolysis Inhibitor)IBA 01/2020
1	prothrombin complex concentrates (PPSB)IBA 11/2019
1	Monoclonal AntibodiesIBA 01/2019
1	Coenzymes (Enzyme Cofactors)IBA 01/2019
1	LigandsIBA 01/2019
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2018
1	Factor VIIIaIBA 01/2017
1	ChemokinesIBA 01/2017
1	CytokinesIBA 01/2017
1	IsoantibodiesIBA 05/2016
1	Interferon LambdaIBA 06/2014
1	ThrombomodulinIBA 09/2013
1	AntigensIBA 07/2010
1	Chemokine CCL4IBA 07/2010
1	sugar formulated recombinant FVIIIIBA 01/2008
1	A-factor (Streptomyces)IBA 05/2006
1	SolventsIBA 05/2006
1	Fibrinogen (Factor I)FDA Link 05/2006
1	Detergents (Detergent)IBA 05/2006

Therapy/Procedure

30	Therapeutics 05/2021 - 02/2002
6	Injections 04/2020 - 09/2016
3	Minor Surgical Procedures (Minor Surgery) 07/2021 - 05/2006
2	Operative Surgical Procedures 01/2020 - 08/2005
1	Platelet Transfusion (Blood Platelet Transfusions) 04/2022
1	Perioperative Care 01/2020
1	Perioperative Period 11/2019
1	Arthrodesis 11/2018
1	Polypharmacy 09/2018
1	Deprescriptions 09/2018
1	Highly Active Antiretroviral Therapy (HAART) 01/2015
1	Orthopedic Procedures 10/2013
1	Arthroplasty 07/2009
1	Knee Replacement Arthroplasty (Total Knee Replacement) 04/2009
1	Prostheses and Implants (Prosthesis) 04/2009